'I've never been this good' – revolutionary immune reset puts lupus in remission
Patients on the trial have not needed medication to manage their condition.
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Notable Quotes
"I've never been this good"
— Katie Tinkler , Other
"It's amazing. I'm living like a normal person, I'm literally saying yes to anything."
— Katie Tinkler , Other
"If we were to have patients in remission for three-to-five years consistently, that would be a major gain in lupus, it may be longer than that, but we'll have to wait and see."
— Dr Maria Leandro , Academic
"These findings are truly groundbreaking and offer fresh hope to people living with lupus."
— Professor Karl Peggs , Academic
"These findings provide early evidence that CAR T-cell therapy may be able to reset the immune system and drive meaningful clinical improvements after a single treatment."
— Dr Claire Roddie , Academic
"Thinking about how life was for beforehand and how it is now, it’s like night and day."
— Katie Tinkler , Other
"These findings are truly groundbreaking and offer fresh hope to people living with lupus."
— Prof Karl Peggs , Academic
"the treatment gave her her life back: the functioning of her internal organs was fully restored, the pain syndrome vanished, and for the first time in a decade, she was able to return to an active daily routine and sports."
— Katie Tinkler , Other
"if sustained remission is maintained in patients for 3 to 5 years, it will be a massive step toward ultimately curing the disease."
— Dr. Maria Leandro , Academic
"These findings are truly groundbreaking and offer fresh hope to people living with lupus."
— Professor Karl Peggs , Academic
"These findings provide early evidence that CAR T-cell therapy may be able to reset the immune system and drive meaningful clinical improvements after a single treatment."
— Dr Claire Roddie , Academic
"Thinking about how life was for beforehand and how it is now, it’s like night and day."
— Katie Tinkler , Other
Key People
Dr Claire Roddie is an investigator on the trial from UCL Cancer Institute and a UCLH consultant haematologist.
Dr Maria Leandro is a consultant rheumatologist at University College London Hospitals.
A consultant rheumatologist at University College London Hospitals.
Katie Tinkler is a lupus patient who participated in an experimental treatment that reset her immune system.
Professor Karl Peggs is the director of UCLH’s biomedical research centre.
Director of UCLH’s biomedical research center, involved in lupus treatment research.
Tags
All Coverage
Patients on the trial have not needed medication to manage their condition.
Five out of six patients with severe lupus achieved remission after receiving CAR T-cell therapy in a UK trial, marking a significant advancement in treatment options.
A pioneering 'immune reset' treatment using CAR T-cell therapy has led to remission in severe lupus patients, potentially eliminating the need for lifelong medication.
Five lupus patients in England achieved remission after being treated with a revolutionary therapy that genetically modifies their own cells, offering a potential cure.
Early clinical trials in the UK have shown that CAR-T therapy can reset the immune system, leading to long-term remission in lupus patients.
An experimental genetic modification therapy has successfully placed severe lupus into remission for British patients during early clinical trials in England, offering a potential cure for the chronic autoimmune disease.
Patients with severe lupus have achieved remission following a groundbreaking 'immune reset' treatment on the NHS, marking the first time in the UK that CAR T-cell therapy has been used for the condition.
Early results from a UCL and UCLH-led clinical trial suggest that CAR T-cell therapy could offer a new treatment approach for people with severe, treatment-resistant lupus.
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